Broad-Scale Identification of White Matter Proteins and their Differential Expression in CADASIL
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Authors
Greenstone, Stanton E.
Issue Date
2021
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
This Study: There were two hypotheses for this study: 1) We
would identify a novel list of proteins preferentially
expressed in the white matter of the brain; 2) we expected to
see diminished levels of protein expression in the white
matter of CADASIL brains compared to controls.
Background: Cerebral autosomal dominant arteriopathy with
subcortical infarcts and leukoencephalopathy (CADASIL) is
an inherited disease that causes damage to the small
penetrating vessels in the white matter of the brain. This
leads to recurrent strokes, subcortical infarcts, eventually
resulting in degeneration of the white matter. As such, it was
thought that the expression levels of proteins in these
damaged regions of the white matter would be diminished.
However, very little research has focused on the discovery of
proteins specific to the white matter.
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.