Steroid hormone regulation of PIK3IP1, a known suppressor of PI3K induced cell division and survival, in the mouse uterus
Abstract
Steroid hormones are essential regulators of uterine function.
AT-rich interaction domain 1A protein (ARID1A) plays an
important role in steroid hormone signaling in endometrial
function and pregnancy. Phosphatidylinositol-3-kinase
interacting protein 1 (Pik3ip1), a known negative regulator of
PI3K induced cell division and survival, is a direct
downstream target of ARID1A, making it a gene of interest
within endometriosis and female fertility.