Steroid hormone regulation of PIK3IP1, a known suppressor of PI3K induced cell division and survival, in the mouse uterus

Abstract

Steroid hormones are essential regulators of uterine function. AT-rich interaction domain 1A protein (ARID1A) plays an important role in steroid hormone signaling in endometrial function and pregnancy. Phosphatidylinositol-3-kinase interacting protein 1 (Pik3ip1), a known negative regulator of PI3K induced cell division and survival, is a direct downstream target of ARID1A, making it a gene of interest within endometriosis and female fertility.