T1R2 and T1R3 knockouts demonstrated significant attenuation of fructose-induced, salt-sensitive hypertension
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Authors
Eaton, Andrew J.
Issue Date
2018
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Increased fructose consumption apparent in the Western diet leads to an
increased risk for hypertension, or chronic high blood pressure. In cases of
individuals pre-disposed to volatile blood pressure increase in the presence of
a high-salt diet, salt-sensitive hypertension can develop due to excess fructose
absorption in the gastrointestinal tract. Taste receptors on the tongue, namely
of the T1R family, play a key role in fructose absorption. Specific receptors
T1R2 and T1R3 transmit nerve signals to the brain, initiating absorption of
fructose in the gastrointestinal tract. The reliance on T1Rs to control fructose
absorption makes them an intriguing cellular component to attempt to
moderate hypertension onset.
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.