T1R2 and T1R3 knockouts demonstrated significant attenuation of fructose-induced, salt-sensitive hypertension

Abstract

Increased fructose consumption apparent in the Western diet leads to an increased risk for hypertension, or chronic high blood pressure. In cases of individuals pre-disposed to volatile blood pressure increase in the presence of a high-salt diet, salt-sensitive hypertension can develop due to excess fructose absorption in the gastrointestinal tract. Taste receptors on the tongue, namely of the T1R family, play a key role in fructose absorption. Specific receptors T1R2 and T1R3 transmit nerve signals to the brain, initiating absorption of fructose in the gastrointestinal tract. The reliance on T1Rs to control fructose absorption makes them an intriguing cellular component to attempt to moderate hypertension onset.