Effect and Mechanism of AS2S2 on DNA Methylation of F-36P Cell Line Derived from Myelodysplastic Syndromes

Abstract

We used MDS-derived F-36P cell to test the effect of the AS2S2 on DNA methylation. Furthermore, we used effect of the AS2S2 on DNA methylation of leukemia-derived HL-60 cells to compare with F-36P cells. Our hypothesis is that the AS2S2 has double effects on the DNA, which is regulation of hypermethylation and hypomethylation. The result showed that AS2S2 had double effects, hypermethylation and hypomethylation, which is proved on the F-36 cells.