Altered Eicosanoid Metabolism Associates with the Salutatory Changes of Salt Restriction in Chronic Kidney Disease

Abstract

Chronic Kidney Disease (CKD) is a global health crisis affecting 11 to 13% of people worldwide. It often coincides with the development of hypertension, making hypertension a critical predictor of CKD progression. Hypertension is generally linked to increased salt intake and can be treated with antihypertensive drugs and/or a salt restricted diet (SRD). However, antihypertensive medications don’t work in patients with salt sensitivity, which means their only treatment option is a salt restricted diet. Diagnosis of salt sensitivity takes time, since the current method of identification is inconvenient and tedious. As more hypertensive patients have become salt sensitive, the necessity of a simpler, more effective identification method has increased. Current studies are focusing on finding potential biomarkers of salt sensitivity, but little is done in patients with CKD. Our study aimed to identify potential eicosanoid metabolites as salt sensitivity biomarkers in CKD patients by studying their concentration changes in response to SRD.