The Characterization of Dicer 1 and Ago 2 in Eutopic and Ectopic Endometrium in the Olive Baboon ( Papio anubis) Incoculated with Endometriosis

Abstract

Endometriosis is a gynecological disease that is characterized by the presence of endometrial tissue outside the uterine cavity . This disease causes chronic inflammation, intense pain , and in many instances leads to infertility among women . The pathogenesis of endometriosis is still unknown. However, m icroRNA had been shown to play critical roles in many gynecological disorders including endometriosis, thus, this study aims to determine the expression profiles of the mechanistic proteins (AGO 2 and Dicer 1 ) behind microRNA biogenesis. Results revealed aberrant levels of AGO 2 protein in glandular endometrial cells between tissue types. The role AGO 2 has in microRNA biogenesis, in context with our results, suggest that it plays a critical part in the expression of genes involved with apoptosis and other responses associated with endometriosis , likely contributing to the pathophysiology of the disease. Our results for Dicer 1 were inconclusive.