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Now showing items 1-10 of 58
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The Oligomerization of Mutant Superoxide Dismutase-1 into Toxic Detergent Insoluble Species Observed in Famililal Amyotrophic Lateral Sclerosis
(Kalamazoo College, 2004)Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in paralysis and death due to motor neuron degeneration in the brainstem and spinal cord. The genetically linked familial form of ALS (fALS) ... -
Ethanol Prolongs Clearance of Exogenous Serotonin in the Dorsal Hippocampus but not the Dorsal Raphe Nucleus of Rat Brain
(Kalamazoo College, 2004)There is a large body of research connecting dysfunction of serotonergic neurotransmission with alcoholism. The serotonin transporter (SERT) is an important element in the regulation of serotonin (5-HT) neurotransmission ... -
Manipulation of Ground Predator Populations Affects Prey Removal in a Highbush Blueberry (Vaccinium corimbosum) Field
(Kalamazoo College, 2004)Arthropod predators such as carabid beetles (Coleoptera: Carabidae) can be effective natural enemies of pests in agroecosystems. In this experiment, the ground arthropod community in a highbush blueberry field (Vaccinium ... -
Purification of a Bacteriocin-like Inhibitor by Enterococcus faecium Strain 62-6 Antagonistic to the Growth of Vaginal Lactobacilli: Potential Significance for the Pathogenesis of Bacterial Vaginosis
(Kalamazoo College, 2004)Bacterial vaginosis is a polymicrobial syndrome characterized by a shift in the ecology of the normal vaginal microflora. This includes a decline in both the prevalence and concentration of Lactobacillus populations that ... -
Analysis of the Alcohol Dehyrogenase (ADH3) and the Serine Protease Inhibitor, Kazal type 1 (SPINKl) Genes in Alcohol-Induced Pancreatitis
(Kalamazoo College, 2004)Alcohol dehydrogenase (ADH3) polymorphisms and serine protease inhibitor, Kazal type 1 (SPINK1) mutations, particularly N34S, have been examined in pancreatitis patients, although no study has analyzed both genes in the ... -
Properties of Breast Epithelial Cancer Cell Line after Treatment with Modified Citrus Pectin and the Transfection of Non-galectin-3 Expressing Cell Line with Cleaved-Galectin-3 cDNA
(Kalamazoo College, 2004)This study aims to expand the work done with modified citrus pectin (MCP) by using a new line of breast preneoplastic epithelial cells, EIII8s. The unique capability of this cell line included its ability to form ductal ... -
Pharmacokinetic and Pharmacodynamic Analysis of Loperamide in mdrla +/+ and -/- Mice
(Kalamazoo College, 2004)The division between the central and peripheral nervous system (CNS; PNS) is known as the blood brain barrier (BBB). One function of the BBB is to regulate transport between the central and peripheral compartments through ... -
Establishing a Protocol for the Detection of Gene Duplications in Drosophila melanogaster
(Kalamazoo College, 2004)Duplication is one of the main mechanisms to introduce new genes into a genome. Once duplicated, evolutionary forces will act upon novel genes causing them to either disappear or become fixed in the population. Previous ... -
Manipulation of the Cellular Redox State: Effects of Antioxidants on TRAIL-induced Apoptosis in Rhabdomyosarcoma Cells
(Kalamazoo College, 2004)Cancer is characterized by the dysfunction of numerous proteins associated with the regulation of cell growth, leading to uncontrolled proliferation. Therefore, the selective induction of cell death in transformed ... -
Construction of His-tagged ATR Fusion Proteins: Working toward the Identification of ATR-interacting Proteins
(Kalamazoo College, 2004)The protein kinase A TR is responsible for initiating signal transmission at cell cycle checkpoints. A TR is a 303 kDa protein containing a carboxy-terminus kinase domain related to PI-3 kinase, and is homologous to the ...
