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Characterization of Polyoma T Antigens Through Immunological Studies
(Kalamazoo College, 1981)Polyoma, a virus shich induces tumors in rodents, encodes three proteins involved in the process of tumorigenesis: the large, middle, and small T antigens. Two projects were performed with the goal of eventually ... -
Determinants of the Ingestion Rate of Filter-Feeding Blackfly Larvae (Diptera: Simuliidae)
(Kalamazoo College, 1981)Feeding activity was investigated in filter-feeding blackfly larvae (Diptera: Simuliidae) under simulated stream conditions. The effect of food availability and feeding history on feeding activity of these larvae was ... -
The Effect of Thiamine on Lead Poisoning in Rats
(Kalamazoo College, 1981)A safe effective method for treatment of lead poisoning is needed. Thiamine (Vitamin B1 ) has been shown to interact with lead in the body. The fact that thiamine is a cheap, readily available, non-toxic substance makes ... -
A Mechanism for the Increased Sensitivity to Benzodiazepines in Hepatocellular Failure: Evidence from an Animal Model
(Kalamazoo College, 1981)Patients with severely impaired hepatocellular function are known to exhibit increased sensitivity to the neuroinhibitory actions of hypnotic drugs, such as benzodiazepines. This study was designed to determine whether ... -
The Effect of 15(s)-Methyl Prostaglandin E1 on Glomerulonephritis in MRL-1pr/1pr Mice
(Kalamazoo College, 1981)Systemic lupus erythematosus (SLE) is a disease affecting humans in various organs. The kidneys, spleen, brain, joints, heart, gastrointestinal tract and lymphatic tissue all show symptoms associated with an auto-immune ... -
Larval Insects Boring in the Roots of Perennial Broomweed (Gutierrezia Sp.) In West Texas
(Kalamazoo College, 1981)Rangeweeds in the Southwestern United States present a serious problem to agriculture. The density of native weeds has increased dramatically due to a change in the range ecosystem from an area periodically grazed to ... -
An In vivo Study of the Role of Opiates in Schizoprenia. 3H-Spiroperidol Binding
(Kalamazoo College, 1981)Since the 1950's, the development of antipsychotic drugs has lead to several physical models for schizophrenia. The preferred model is the Dopamine hypothesis, which relates schizophrenia to a malfunction of the ... -
Effect of Photobleaching on the Viability of Hamster Fibroblast NIL-8M2 Cells
(Kalamazoo College, 1981)Fluorescence recovery after photobleaching (FRAP) is a technique employed to estimate diffusion coefficients of membraneous components. Fluorescent labels, when exposed to high intensity light and molecular oxygen, are ... -
Qualitative Studies on the Interconversion of High Density Lipoproteins Facilitated by the Plasma Lipid Transfer Complex
(Kalamazoo College, 1981)Human lipoprotein-free plasma contains proteins which facilitate the movement of cholesteryl ester, phospholipid, and triglyceride between the various lipoprotein particles. During lipolysis of very low density lipoproteins ... -
Two-Dimensional Gel Electrophoretic Analysis of Urinary Proteins in the Sprague-Dawley Rat
(Kalamazoo College, 1981)Proteinuria is a symptom common to male Sprague-Dawley rats with chronic progressive nephrosis. Albumin and other high molecular weight proteins are excreted in the urine as rats age. In these experiments urine, serum, ...