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In glutathione-monochlorobimane assay with human microsomes, increased glutathione concentration and pre-incubation with NADPH and ABT overcomes signal reduction
(Kalamazoo College, 2007)Glutathione (GSH) is a powerful antioxidant that is vital to cell health to prevent oxidative stress and toxicity. One mechanism of detoxification is through conjugation by glutathione S-transferase (GST) to harmful ... -
Evaluation of Microbial Diversity in Ophiolite-Hosted Cold Springs as an Analog to Martian Environments
(Kalamazoo College, 2007)The exploration of ophiolites,as an analog to Martian environments,may be useful in devising a search strategy for life on Mars. Oceanic settings, dominated by mafic and ultramafic rocks interacting with seawater and ... -
Use of Continuous Culture to Model Recurrent Bacterial Vaginosis
(Kalamazoo College, 2007)Bacterial vaginosis (BV) is the most common vaginal tract infection seen in women of childbearing age in primary health care. In this polymicrobial condition, an alteration of vaginal microflora occurs where the lactobacilli ... -
Periventricular Expression of Megalin in Adult Male Rat Brains and In-Vitro SHBG Binding to Cells Through Interaction with a Megalin Receptor
(Kalamazoo College, 2007)Sex Hormone Binding Globulin (SHBG) carries androgens and estrogens throughout the body to specific target cells. It was previously believed that SHBG transported its cargo outside of target cells, and the hormones then ... -
Where will they go? : Cryptomonas erosa vertical distribution in a poorly mixed water column with nutrient and light gradients
(Kalamazoo College, 2007)In inland lakes, light and nutrients form gradients within the water column. Mathematical models have been used to show that algae can form thin layers within the water column at some depth to maximize light and nutrient ... -
The Effects of Fertilization and Heterogeneity On the Growth Strategies of Clonal Plants
(Kalamazoo College, 2007)Theory predicts that species diversity increases with increasing heterogeneity, although very few field experiments have found evidence to support it. One possible reason for a lack of evidence in some communities is ... -
Resistance to Daptomycin in the Treatment of Methicillin Resistant Staphylococcus aureus Bacteremia
(Kalamazoo College, 2007)Staphylococcus aureus is an aerobic gram positive bacterium that can cause harmful skin infections and bacteremia. Some strains of S. aureus have become resistant to synthetic penicillin (Methicillin) and therefore need ... -
The Effects of DNA-PKcs Deficit on Cellular Senescence and Intrauterine Growth in Canine Models of Severe Combined Immunodeficiency
(Kalamazoo College, 2007)DNA double strand breaks (DSBs) are among the most dangerous forms of DNA damage and their repair is essential to maintain genome integrity. Umepaired or misrepaired DSBs can lead to chromosome aberrations, apoptosis, ... -
The role of CD23+ B cells in host protection against Schistosoma mansoni
(Kalamazoo College, 2007)Schistosomiasis caused by three main species of parasitic trematodes affects over 207 million people worldwide. Individuals who are resistant to reinfection with schistosomes have an increased percentage of CD23+ B cells, ... -
Effects of short-term culture on the physiology of mitochondrion-rich cells in the opercular membrane of Fundulus heteroclitus
(Kalamazoo College, 2007)Mitochondrion-rich cells (MRCs) are crucial to most of the physiological processes in gills that allow marine teleosts to osmoregulate. Direct physiological studies of gill function are difficult because the teleost gill ...