Determining the Correlation between Optic Nerve Head Neuroretinal Rim Area and Retinal Functioning for Primary Open-Angle Glaucoma in Dogs with an ADAMTS10 Gene Mutation
Avery, Brooklyn D.
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Glaucoma is one of the leadings causes of irreversible blindness worldwide and can be characterized by damage to the optic nerve, causing increased intraocular pressure and loss of retinal ganglion cells, resulting in a decrease in structural integrity and visual functioning. While open-angle glaucoma is well defined, it is unclear how the degradation of structural and function parameters influence each other as the disease progresses. Primary open-angle glaucoma in dogs is a type of inherited glaucoma. A glycine to arginine substitution in the ADAMTS10 gene in beagles is an autosomal recessive mutation and has been linked to the development of primary open-angle glaucoma. In this study, members of an ADAMTS10 mutant beagle colony at Michigan State University underwent optical coherence tomography imaging to measure changes in the neuroretinal rim area as a structural parameter to track progression of glaucoma. Dogs also underwent electroretinography recording to measure the changes in 10 functional parameters of the eye as glaucoma progressed. Using R, a repeated measurement correlation technique was used to determine the correlation between changes in neuroretinal rim area and age, changes in the 10 functional parameters and age, and changes in neuroretinal rim area and changes in the 10 functional parameters. Almost all structural and functional parameters showed a significant correlation with the other measured variables. These results led us to conclude that there is a significant correlation between changes in structural parameters and functional parameters as glaucoma progresses. Due to this pattern in our results, these measurements were determined to be good parameters to indicate significant changes for early detection of primary-open angle glaucoma in dogs with an ADAMTS10 mutation.