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Chemistry Senior Integrated Projects: Recent submissions
Now showing items 1-20 of 934
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Towards the Synthesis of Neuroprotective Dictyoquinazol Derivatives
(Kalamazoo College, 2023-03-01)The need for more efficacious neuroprotective pharmacophores has been in high demand during recent years with 795,000 people suffering from strokes every year in the United States alone. Dictyoquinazols may help lead to ... -
Yersinia pestis Adhesins’ Role in Yop Delivery to Neutrophils and Bacterial Survival Using the Neutrophil-like Cell Line HL-60
(Kalamazoo College, 2022-11-01)Yersinia pestis is a gram-negative, bacillus bacteria that is the causative agent of the bubonic plague. This strain of Yersinia has been responsible for killing millions of people in history, most notably during the ... -
Exploring a Sponge-Derived Leucobacter sp. as a Potential Source for Antibiotics
(Kalamazoo College, 2023-01-01)Antibiotic resistance is a rising global health concern. Many of the current antibiotics produced by microorganisms are derived from well researched bacteria such as the genus Streptomyces. Though Streptomyces is a remarkable ... -
Synthesis of Plasmenyl PC and PE Polar Lipids
(Kalamazoo College, 2023-03-01)Plasmalogens are a type of polar lipid that are found naturally throughout the human body. These compounds are categorized as plasmalogens by a vinyl ether bond and an ester linked fatty acid chain. The plasmalogens in ... -
Methods for the Separation of Acylated Surfactant Precursors from Fatty Acids
(Kalamazoo College, 2023-03-01)A widely used commercial surfactant, linear alkyl-benzene sulfonate surfactant (LAS), is produced from fossil fuel molecules and requires the incorporation of chelating agents such as metal chelants, increasing complexity ... -
The Route Development Towards Dicytoquinazol A Analogs to Investigate Neuroprotective Activity Against Glutamate Excitotoxicity
(Kalamazoo College, 2023-03-01)Multiple Sclerosis (MS) is a chronic neurological disease that impacts millions every year and cases continue to grow. A hypothesized mechanism that contributes to MS is glutamate excitotoxicity. A natural product shown ... -
Towards the Synthesis of Temozolomide Theragnostic Derivatives
(Kalamazoo College, 2022-11-01)Glioblastoma multiforme (GBM) is the most common and proliferating primary brain tumor with a median survival of 12-15 months. GBM is characterized as having extreme cell proliferation which diffuses throughout the brain ... -
Membrane Protein Energy Functions for De Novo Design of Transmembrane β-Barrels
(Kalamazoo College, 2022-11-01)As the field of proteomics rapidly, the ability to accurately model and design membrane proteins lags. Modeling and designing membrane proteins is notoriously more difficult than modeling and designing soluble proteins ... -
Dental and Chemical Applications of Various Fillings
(Kalamazoo College, 2023-01-11)Imagine a usual trip to the dentist's office. You are always reminded to brush better and to actually floss but if you are a part of around 90% of adults over the age of 20 or about 57% of adolescents under the age of 19, ... -
Design, Synthesis and Evaluation of Tryptophan-Maleimide Hybrids as Potential Antibacterial Agents
(Kalamazoo College, 2022-11-01)The rise in antibacterial resistance poses a threat to public health and national security. In the development of novel antibiotics, there is particular interest in scaffolds that have mechanisms of action with multiple ... -
Towards the Synthesis of 5-Bromo-Tryptamine − 2-Cyclopropyl-Quinazolinone Hybrids as Potential Broad Spectrum Efflux Pump Inhibitors
(Kalamazoo College, 2022-11-01)Efflux pumps (EPs) are trans-membrane proteins that contribute to the rise in drug resistant (DR) bacteria. EPs nullify antibiotics by ejecting them out of the cell before they can perform their mechanism of action. ... -
Investigation into the Reaction Kinetics of the Hydrolysis of Molnupiraivir to 4N-hydroxycytidine
(Kalamazoo College, 2022-11-01)Throughout the COVID-19 outbreak many new pharmaceuticals have been developed to help stop the spread and treat patients suffering from the virus. One of these potential drug candidates is molnupiravir. Molnupiravir is a ... -
Design and Synthesis of 2-Methyl Tryptamine-Maleimide Hybrids as a Potential Antitubercular Agents
(Kalamazoo College, 2022-11-01)Over 2.8 million antibiotic-resistant infections occur every year in the United States. Of these infections, drug-resistant tuberculosis is of particular concern, especially for multi-drug resistant strains. Hybridization ... -
Integration of Personalized Narrative to Inform Improved Communication for Patients with Life-Limiting Illness
(Kalamazoo College, 2022-09-01)Narrative intervention has proven to be an effective method of allowing informed decisions, considering patient comfort, improving treatment outcomes, and more. A narrative intervention approach entails prompting patients ... -
A Review of the Improvement in Diagnostic Accuracy for Acute Heart Failure (INDICATE-HF)
(Kalamazoo College, 2022-11-01)The aim of the current study is to unearth a diagnostic model to improve the ruling-in of heart failure, rather than ruling out. The process of heart failure diagnosis is imperative to prevent recurring hospitalization. ... -
Towards the Synthesis and Characterization of Mn(II) Polypyridyl Complexes for Photochemical Applications
(Kalamazoo College, 2022-11-01)Coordination complexes of transition metals that have long-lived charge-separated excited states have many photochemical applications such as solar energy conversion and photoredox catalysis. The traditionally used transition ... -
Synthesis of Peptoids with Varying Alkyl Side Chains and Urea Functional Groups
(Kalamazoo College, 2022-11-01)Peptoids are N-substituted glycines that act as biomimetic analogs to peptides. Peptoids, like peptides, demonstrate significant changes in conformation based on the substituents attached to them. Whether a peptoid backbone ... -
Synthesis of 2,6-(diquinoline-8-yl)pyridine for Mn(II) Photoactive Complexes
(Kalamazoo College, 2023-01-01)Transition metal complexes with charge-separated excited states show many attractive properties that make them useful in various applications such as solar energy conversion, molecular wires, and photoredox catalysis. This ... -
Examining the Neuroprotective Effects of 7-hydroxy-2-(2-phenylethyl)chromone in Glutamate Excitotoxicity model of C. Elegans
(Kalamazoo College, 2023-01-01)There are 600 neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) that are affecting about 50 million Americans each year. Glutamate excitotoxicity is a ...
