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dc.contributor.advisorBerridge, Kent
dc.contributor.authorDandar, Christina M.
dc.date.accessioned2019-11-08T23:51:23Z
dc.date.available2019-11-08T23:51:23Z
dc.date.issued2017
dc.identifier.urihttps://cache.kzoo.edu/handle/10920/37262
dc.descriptionvii, 59 p.en_US
dc.description.abstractThe survival of an organism depends on its ability to consume natural rewards and avoid aversive stimuli. However, maladaptive pursuits of pleasure can result in affective disorders, such as drug addiction. Here I examined the role of the central nucleus of the amygdala (CeA) in detecting an environmentally salient stimulus: a shock prod. I paired optogenetic channelrhodopsin (ChR2) stimulation in the CeA of male and female rats with a shock prod. When rats entered a l-in. radius around the shock prod, they received 40 Hz of optogenetic blue laser stimulation to the CeA. A second group received no optogenetic stimulation. I predicted that both groups would exhibit fearful behavior. Surprisingly, CeA ChR2 rats did not fear the shock prod. Instead, they pursued it, demonstrating consummatory behaviors towards the prod. By comparison, rats without CeA excitation feared the shock prod, exhibiting defensive behaviors, such as treading. The consummatory behaviors demonstrated by the CeA ChR2 group suggest that incentive salience was attributed to the shock prod, transforming it into an attractive, attention-grabbing object. Fos expression in various brain regions was compared between the two groups and results identified two structures that may explain the difference in behavior between the two groups: the basolateral amygdala (BLA) and ventral pallidum. The results confirm that optogenetic activation of CeA-related circuitry produces narrowly focused yet intense motivation to pursue a reward. However, it also suggests a 'maladaptive' feature of this CeA-generated intense motivation that might be shared with addiction, as the motivation enhancement was towards a threatening and harmful stimulus.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Psychology Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleDangerous Desire : Central Amygdala Excitation Amplifies Attraction Towards Aversive Stimulien_US
dc.typeThesisen_US


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  • Psychology Senior Individualized Projects [722]
    This collection includes Senior Individualized Projects (SIP's) completed in the Psychology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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