Absorption Characteristics of U-63,287 as Evaluated by In Situ Rat Gut Perfusion
Bangs, Mark E.
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This project characterizes the absorption in the rat's Intestines of U-63,287, an oral antidiabetic drug. The method used to study U-63,287's absorption is a modification of an in situ intestinal perfusion technique developed by Schanker et al.(1958). The studies performed during this project include a comparison of the relative absorption rates of U-63,287 in three different intestinal segments, a quantitative analysis of absorption of U-63,287 from the duodenum into the mesenteric lymph, a study of the relationship between perfusate residence time and intestinal absorption, and a study of U-63,287 absorption at different pHs.