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dc.contributor.advisorOndrechen, Mary Jo
dc.contributor.authorCho, Jennifer
dc.descriptionvii, 21 p.en_US
dc.description.abstractAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects the motor neurons in the brain and spinal cord with no effective medication to halt or reverse the symptoms. Although most ALS cases are sporadic and have no known cause, a significant percentage of cases have a genetic association that is caused by the subsequent unfolding and aggregation of superoxide dismutase [Cu, Zn] homodimer. The Ondrechen Research Group has been in works to identify potential cyclic disulfide crosslinking agents to stabilize the ALS associated protein by “tethering” two SOD1 monomers via adjacent Cys111 resides using maleimide chemistry. Initial computational homology modeling, docking simulations, and analyses were conducted to find potential crosslinking agents among 53 cyclic disulfides using YASARA. The initial research resulted in identifying, in total, seven cyclic disulfides as potential crosslinking agents. A couple cyclic disulfides have been computationally determined to be able to stabilize more than one SOD1 variant.en_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleComputational Analysis of Crosslinking Agents With SOD1 in ALS to Inhibit Aggregationen_US

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  • Chemistry Senior Individualized Projects [889]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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