Show simple item record

dc.contributor.advisorFurchak, Jennifer R.W.
dc.contributor.advisorFiegel, Jennifer
dc.contributor.advisorBrogden, Nicole K.
dc.contributor.authorGonzalez, Gil A.
dc.date.accessioned2019-06-01T17:23:40Z
dc.date.available2019-06-01T17:23:40Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10920/37068
dc.descriptionvii, 23 p.en_US
dc.description.abstractPropranolol is a drug that is typically used to treat adult patients with high blood pressure, chest pain, and irregular heartbeats. However, it also has an unknown mechanism to stop and decrease the growth of a benign tumors known as infantile hemangiomas that affect children. One current option to stop the growth of the hemangiomas is corticosteroid treatment, but other treatment options are currently being investigated due to the side effects that are associated with steroids. Propranolol, however, does have some serious side effects that are present with the oral pill form when given to children. Therefore, the option being investigated in this project is to introduce the drug topically to the skin, which would provide lower dosage at a more concentrated area so that side effects would be less likely to occur. The manner of doing this use microemulsion and microneedle systems. The microneedle system help creates pores so that propranolol can go past the outer skin barrier, and the microemulsion system can be used to help encapsulate propranolol to permeate through the skin. Varying concentrations of propranolol were found to have little to no effect on the formulation of microemulsions. The microneedles were found to help increase the permeation of propranolol compared to skin that did not get treated with microneedles. With this information, the systemic release of propranolol could be decreased using the microemulsions and microneedles. This could lead to a safer, but still effective, dosage of propranolol for children that are being affected by infantile hemangiomas.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleMicroneedle Skin Delivery of Propranolol using Microemulsionen_US
dc.typeThesisen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • Chemistry Senior Individualized Projects [889]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

Show simple item record