Microneedle Skin Delivery of Propranolol using Microemulsion
Gonzalez, Gil A.
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Propranolol is a drug that is typically used to treat adult patients with high blood pressure, chest pain, and irregular heartbeats. However, it also has an unknown mechanism to stop and decrease the growth of a benign tumors known as infantile hemangiomas that affect children. One current option to stop the growth of the hemangiomas is corticosteroid treatment, but other treatment options are currently being investigated due to the side effects that are associated with steroids. Propranolol, however, does have some serious side effects that are present with the oral pill form when given to children. Therefore, the option being investigated in this project is to introduce the drug topically to the skin, which would provide lower dosage at a more concentrated area so that side effects would be less likely to occur. The manner of doing this use microemulsion and microneedle systems. The microneedle system help creates pores so that propranolol can go past the outer skin barrier, and the microemulsion system can be used to help encapsulate propranolol to permeate through the skin. Varying concentrations of propranolol were found to have little to no effect on the formulation of microemulsions. The microneedles were found to help increase the permeation of propranolol compared to skin that did not get treated with microneedles. With this information, the systemic release of propranolol could be decreased using the microemulsions and microneedles. This could lead to a safer, but still effective, dosage of propranolol for children that are being affected by infantile hemangiomas.