Effect of Using Angiotensin Converting Enzyme Agents, Sex, Diabetes, and Blood Pressure on the Decline in Glomerular Filtration Rate in ADPKD Patients
Kesho, Reesha B.
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Autosomal dominant polycystic kidney disease (ADPKD) affects millions of individuals. It is one of the most common diseases requiring renal replacement therapy. There have been many advances in the understanding of the disease’s genetics, in the diagnosis and management, and in the various treatment options available. However, it is unclear if any factors besides genetics play a role in the development of this disease. We tested various factors that impacted glomerular filtration rates (GFR) in ADPKD patients. The presence of diabetes, blood pressure, sex, GFR, and use of angiotensin converting enzyme (ACE) inhibitors were analyzed from patient records. We found no relationship between GFR and use of ACE inhibitors, sex, or diabetes. Finally, we determined that blood pressure, diabetes, and use of ACE inhibitors have an impact on GFR. Through this study and future studies, we can determine the importance of ACE inhibitors on maintaining GFR in patients with diabetes or hypertension. From this, we can develop targeted medications other than ACE inhibitors to maintain and improve kidney function. We can further find new diagnosis methods such as looking at kidney function in diabetic or hypertensive patients.