Comparing Mean Alveolar Concentration, Heart Rate, and Recovery Time in Canines when Anesthetically Induced via Alfaxalone or Propofol
Mason, Hannah L.
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This study compares a relatively newly released drug, alfaxalone, and an older, reliable drug that many veterinarians trust, propofol. The data collected is compared to determine if one drug is more effective than the other, specifically with regards to mean alveolar concentration (MAC), heart rate under anesthesia, and post-operative recovery. It is hypothesized that alfaxalone and propofol will have similar inductions but alfaxalone will lead to faster recovery times based on previous research. It is also hypothesized that administering pre-anesthetic medication would help subjects maintain a more normal heart rate, lower MAC throughout the procedure, and shorten recovery times. MAC, heart rate, and recovery time are monitored in canine subjects for minimally invasive procedures such as laceration repairs induced with either propofol or alfaxalone. ANOVA and t-tests are run to examine how alfaxalone and propofol compare between MAC, heart rate, and recovery times which are assessed by the time it took for the subject to be extubated, to lie sternally, and to stand. These same parameters are examined within alfaxalone and propofol but by looking at the presence ofpre-anesthetic medication versus the absence of premedication. It was determined that there is no significant difference found between MAC, heart rate, or recovery times for propofol versus alfaxalone. There was also no significant difference between premedication and no premedication for alfaxalone or propofol except for the average heart rates within the alfaxalone subjects which were lower when pre-anesthetic medication was given. This study can demonstrate that the newer drug alfaxalone is equally effective and cardiovascularly sparing as propofol. It also confirms that even though alfaxalone is newer and marketed as superior, it does not demonstrate any ground-breaking benefits over propofol when using the selected objective monitoring parameters.