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    Synthesis of High Value 4-hydroxy and 4-oxo Pipecolic Acid Derivatives from a Process Byproduct

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    Date
    2009
    Author
    Newcomb, Eric
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    Abstract
    Functional transformations of4-substituted pipecolic acid derivatives are described. Many 4-substituted pipecolic acid derivatives are found throughout nature and within many pharmaceutical targets. The goal of this research involved recycling a pipecolic acid byproduct in order to make useful, marketable compounds. The highlight ofthe transformations includes an oxidation reaction with a TEMPO radical catalyst. Overall yields were 20% in three steps and 55% in two steps to the respective ketone products. Additionally, a Wittig reaction followed by a selective reduction on a 4- oxopipecolic acid product to produce a protected carboxylic acid at position-4 was explored.
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    http://hdl.handle.net/10920/35633
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