Solid Phase Heck Reaction Catalysis : An Exploration of Reaction Component Modification
Korn, Marc A.
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Described within this report is a detailed analysis and investigation of the Heck reaction using solid phase heterogeneous catalysts. Usinga diol spacer and a phenanthroline ligand, transition metal compounds could be complexed to the solid state and used to drive reactions. This specific preparation allowed for easy separation and potential recycling of the catalysts. Through modification and comparison, components of the catalytic system were studied to determine their impact on reactivity and selectivity. Increasing spacer length showed minimal improvement in catalytic activity. This result differs from previous spacer length experiments (Robinson 2007). Additionally, using a transition metal complex with greater leaving group tendency showed an increase in reactivity. Using GCMS and the implementation of an internal standard, a predictable and efficient method for normalization and product quantification was developed.
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