Preparation and Demonstrated Activity of Immobilized Catalase Mimic
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Catalase has been studied and observed for many years due to its unique ability to decompose hydrogen peroxide into water and molecular oxygen. Many catalase mimics have been previously created to generate molecular oxygen efficiently. Using previous studies as a guide, a simple catalase mimic without a hanging buffering group over the redox center was created and bound to a Wang resin solid support system. The system successfully generated molecular oxygen from hydrogen peroxide at a rate of 1.39 x 10"5 mmol of oxygen per mg of resin per second. The immobilized catalyst was recyclable and generated oxygen at a rate of 3.6 x 10" mmol O2 per mg of resin per second after one cycle. Studies showed that the reaction was first order with respect to the amount of the resin. The catalyst was also successful and recyclable in an aqueous environment but proved to be more proficient in organic solvents. In addition, a synthetic scheme was studied to prepare 2-(3,4-diaminophenyl)-2,2-dimethylpropanoic acid which when loaded with manganese and attached to the solid phase support would generate a more complex system with a pendent acid-base functional group over the redox center in order to increase the productivity and efficiency of the catalase mimic.