Development Of A Molecular Beacon For Mammaglobin For The Early Detection Of Breast Cancer Metastasis
Sharma, Vinay K.
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Among cancers, breast cancer has the second highest incidence among women. Fortunately, early detection of the cancer has led to more successful treatment options for patients. Accurate diagnosis of breast cancer metastasis can be obtained by monitoring the presence of multiple biomarkers. The use of molecular beacons serves as a potential way to detect early signs of cancer metastasis by monitoring mRNA biomarker concentrations. Molecular beacons serve as an efficient analytical tool to detect biomarkers due to their high specificity and selectivity for complementary RNA sequences. A concentration-dependent molecular beacon was designed for the breast cancer biomarker mammaglobin. The total time for the assay is significantly shorter than other current methods such as ELISA and RT-PCR. Additionally, the design of a molecular beacon can be improved by the use of a computer algorithm.