| dc.contributor.author | Karamchandani, Jaideep M. | |
| dc.date.accessioned | 2017-02-01T20:04:53Z | |
| dc.date.available | 2017-02-01T20:04:53Z | |
| dc.date.issued | 2009 | |
| dc.identifier.uri | http://hdl.handle.net/10920/30626 | |
| dc.description | 1 Broadside. Original created in Microsoft PowerPoint. 48"W x 36"H | en_US |
| dc.description.abstract | HIV belongs to genus Lentivirus.
HIV spread through sexual contact, blood, and mother to child.
Virus interior is composed of two single-stranded RNA.
Reverse transcriptase is key enzyme used to incorporate virus into DNA.
CCR5 and CXCR4 tropic strains.
Results in death of CD4+ T cells (Helper T cells) through Direct Killing, Increased Apoptosis and Indirect killing of CD8 T lymphocytes (Cytotoxic T cells).
Leads to Acquired Immune Deficiency Syndrome (AIDS) and increased susceptibility to opportunistic infections (e.g. Tuberculosis).
Upon viral entry, DC-SIGN expressed on dendritic cells In vivo has been implicated as a receptor facilitating efficient trans HIV-1 virus transmission to CD4+ T cells.
However, It has been observed that another member of the C-type lectin family, L-SIGN, inefficiently binds and transmits virus. | en_US |
| dc.description.sponsorship | Kalamazoo College. Department of Biology. Diebold Symposium, 2009 | en_US |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Kalamazoo, Mich. : Kalamazoo College | en_US |
| dc.relation.ispartof | Kalamazoo College Diebold Symposium Presentation Collection | en |
| dc.rights | U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. | en |
| dc.title | DC-SIGN Carbohydrate Recognition Domain (CRD) Determinants Responsible for HIV-1 Binding | en_US |
| dc.type | Presentation | en_US |
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