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dc.contributor.authorKaramchandani, Jaideep M.
dc.description1 Broadside. Original created in Microsoft PowerPoint. 48"W x 36"Hen_US
dc.description.abstractHIV belongs to genus Lentivirus. HIV spread through sexual contact, blood, and mother to child. Virus interior is composed of two single-stranded RNA. Reverse transcriptase is key enzyme used to incorporate virus into DNA. CCR5 and CXCR4 tropic strains. Results in death of CD4+ T cells (Helper T cells) through Direct Killing, Increased Apoptosis and Indirect killing of CD8 T lymphocytes (Cytotoxic T cells). Leads to Acquired Immune Deficiency Syndrome (AIDS) and increased susceptibility to opportunistic infections (e.g. Tuberculosis). Upon viral entry, DC-SIGN expressed on dendritic cells In vivo has been implicated as a receptor facilitating efficient trans HIV-1 virus transmission to CD4+ T cells. However, It has been observed that another member of the C-type lectin family, L-SIGN, inefficiently binds and transmits virus.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2009en_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleDC-SIGN Carbohydrate Recognition Domain (CRD) Determinants Responsible for HIV-1 Bindingen_US

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  • Diebold Symposium Posters and Schedules [479]
    Poster and oral presentations by senior biology majors that include the results of their Senior Integrated Projects (SIPs) at the Diebold Symposium. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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