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dc.contributor.authorTam, Amy
dc.description1 Broadside. Original created in Microsoft PowerPoint. 48"W x 36"Hen_US
dc.description.abstractHead and neck cancer, as the sixth most prevalent cancer in the world, has treatment options including surgery, radiotherapy, or both. Distraction osteogenesis (DO) is a new surgical method that helps remediate harmful side effects from radiation and is less invasive than bone grafting, but has a lengthy recovery time. In previous experiments done at the University of Michigan’s Medical Center, drug treatments like amifostine and deferoxamine have been shown to reduce the length of rehabilitation by acting as a cellular radio protectant and promoting angiogenesis, respectively. However, metrics measured have not been completely restored back to non-radiated levels when analyzing bony union rate and mechanical testing. In this study, both individual treatments were combined in order to try and maximize their therapeutic potential. Hypothesis: A combination therapy of amifostine and deferoxamine will improve biomechanics and union rates beyond either therapy alone following radiotherapy and distraction osteogenesis.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2016en_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleA Combination Drug Therapy For Bone Regeneration Using A Model of Distraction Osteogenesis Following Radiotherapyen_US

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  • Diebold Symposium Posters and Schedules [479]
    Poster and oral presentations by senior biology majors that include the results of their Senior Integrated Projects (SIPs) at the Diebold Symposium. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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