Show simple item record

dc.contributor.advisorQin, Zhihui
dc.contributor.authorKuntzman, Matthew T.
dc.date.accessioned2016-05-14T14:03:33Z
dc.date.available2016-05-14T14:03:33Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10920/30352
dc.descriptionvi, 22 p.en_US
dc.description.abstractProstate cancer affects more men in the United States than any other cancer with projections estimating that 220,800 men will be diagnosed in 2015. Advancements in drug design and research have substantially decreased the mortality of prostate cancers, however, the prevalence and incidence of the disease still displays the need for more effective treatments. A recently discovered class of molecules found in cruciferous vegetables, isothiocyanates (ITCs), has shown promise in treating prostate cancer cell lines, one of the molecules being phenethyl isothiocyanate (PEITC). It was noticed that enzalutamide, a drug used to treat castration resistant prostate cancer (CRPC), and PEITC have some similar structural features. A drug was rationally designed using the structures of PEITC and enzalutamide with the intent of working as a dual-action chemotherapeutic against prostate cancer. In this study, a critical intermediate, 4-(3-(6-(2-isothiocyanatoethyl) pyridin-3-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl) benzonitrile, was successfully synthesized providing a potential synthetic route the dual-action chemotherapeutic. We hypothesize the synthetic route offered by this study will yield success in the synthesis of a novel anti-prostate cancer drug.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleSynthesis of a Novel Dual-Action Intermediate for the Chemotherapeutic Treatment of Prostate Canceren_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • Chemistry Senior Individualized Projects [889]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

Show simple item record