ABOUT K
ACADEMICS
ADMISSION
ALUMNI RELATIONS
GIVING TO K
NEWS & EVENTS
STUDENT LIFE
HORNET HIVE
ATHLETICS
SITEMAP
WEBMAIL
    • Login
    View Item 
    •   DSpace Home
    • Academic Departments, Programs, and SIPs
    • Chemistry
    • Chemistry Senior Individualized Projects
    • View Item
    •   DSpace Home
    • Academic Departments, Programs, and SIPs
    • Chemistry
    • Chemistry Senior Individualized Projects
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Synthesis of a Novel Dual-Action Intermediate for the Chemotherapeutic Treatment of Prostate Cancer

    Thumbnail
    View/Open
    Kuntzman-MatthewSIP.pdf (371.1Kb)
    Date
    2016
    Author
    Kuntzman, Matthew T.
    Metadata
    Show full item record
    Abstract
    Prostate cancer affects more men in the United States than any other cancer with projections estimating that 220,800 men will be diagnosed in 2015. Advancements in drug design and research have substantially decreased the mortality of prostate cancers, however, the prevalence and incidence of the disease still displays the need for more effective treatments. A recently discovered class of molecules found in cruciferous vegetables, isothiocyanates (ITCs), has shown promise in treating prostate cancer cell lines, one of the molecules being phenethyl isothiocyanate (PEITC). It was noticed that enzalutamide, a drug used to treat castration resistant prostate cancer (CRPC), and PEITC have some similar structural features. A drug was rationally designed using the structures of PEITC and enzalutamide with the intent of working as a dual-action chemotherapeutic against prostate cancer. In this study, a critical intermediate, 4-(3-(6-(2-isothiocyanatoethyl) pyridin-3-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl) benzonitrile, was successfully synthesized providing a potential synthetic route the dual-action chemotherapeutic. We hypothesize the synthetic route offered by this study will yield success in the synthesis of a novel anti-prostate cancer drug.
    URI
    http://hdl.handle.net/10920/30352
    Collections
    • Chemistry Senior Individualized Projects [820]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
     

     

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

    My Account

    Login

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
     

     

    K logo
    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602
    ABOUT K
    ACADEMICS
    ADMISSION
    ALUMNI RELATIONS
    GIVING TO K
    NEWS & EVENTS
    STUDENT LIFE

    Sitemap
    Map and Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official Disclaimer
    Search this site





    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar