Determination of the Steady State Skin Flux of Two Anti-Parasitic Active Pharmaceutical Ingredients in Canine, Swine, and Bovine Skin
Goodrich, Amber N. Middlebrooks
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Transdermal delivery of drugs is a hugely attractive dosage route combining ease of administration with avoidance of first pass metabolism. The limiting factor to that however is the skin, which has been perfected to be an excellent barrier to foreign substances trying to enter the body. This has led to the question of what species are best equipped for transdermal drug delivery, and what type of molecules are best for transdermal delivery? The steady state flux of two marketed anti-parasitic drugs, Fipronil and Demiditraz, were compared in canine, swine, and bovine skins using a Franz Diffusion Cell system. The flux through each skin was measured over a 48 hour period. Bovine skin showed the greatest steady state flux of all the species over time for both compounds. Canine skin showed the mean flux of the three species, and swine skin had the lowest flux of the three species.Administrator only at request of department, 5/2/2016.