Determination of the Steady State Skin Flux of Two Anti-Parasitic Active Pharmaceutical Ingredients in Canine, Swine, and Bovine Skin
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Authors
Goodrich, Amber N. Middlebrooks
Issue Date
2015
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Transdermal delivery of drugs is a hugely attractive dosage route combining ease
of administration with avoidance of first pass metabolism. The limiting factor to that
however is the skin, which has been perfected to be an excellent barrier to foreign
substances trying to enter the body. This has led to the question of what species are
best equipped for transdermal drug delivery, and what type of molecules are best for
transdermal delivery?
The steady state flux of two marketed anti-parasitic drugs, Fipronil and
Demiditraz, were compared in canine, swine, and bovine skins using a Franz Diffusion
Cell system. The flux through each skin was measured over a 48 hour period. Bovine skin
showed the greatest steady state flux of all the species over time for both compounds.
Canine skin showed the mean flux of the three species, and swine skin had the lowest
flux of the three species.
Administrator only at request of department, 5/2/2016.
Administrator only at request of department, 5/2/2016.
Description
viii, 30 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.