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dc.contributor.advisorKnight, Jason S.
dc.contributor.authorMorris, Alexandra E.
dc.date.accessioned2015-09-12T14:31:27Z
dc.date.available2015-09-12T14:31:27Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10920/29958
dc.descriptionvii, 44 p.en_US
dc.description.abstractAntiphospholipid syndrome is an autoimmune disorder that causes thrombosis and pregnancy complications with no targeted treatment available. Antiphospholipid antibodies (aPLs) against β2GPI have been known to activate monocytes, platelets, and endothelial cells, leading to vascular damage and clot formation. Neutrophil extracellular traps (NETs) are a recently discovered phenomenon known to have both arterial and venous pro-thrombotic implications, however their relationship with aPLs has not been previously studied. This research examined the link between aPLs and neutrophils, investigating whether these antibodies induce NET formation, leading to thrombosis. Indeed, β2GPI was found on both resting neutrophils and NETs and β2GPI appears to be present at extremely high levels when NETs are induced in the presence of plasma. Furthermore, β2GPI-DNA complexes form not just in vitro, but were also detected at significantly higher levels in APS plasma and serum samples as compared to healthy controls. Additionally, β2GPI appears to co-localize with CD32a on neutrophils with potential for modulating downstream effects. Thus, it was determined that aPLs interact with NETs, providing the basis for a novel therapeutic target for APS.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleAntiphospholipid Antibodies Interact with Neutrophil Extracellular Traps: a Novel Mechanism of Thrombosis in the Antiphospholipid Syndromeen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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  • Chemistry Senior Individualized Projects [889]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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