JavaScript is disabled for your browser. Some features of this site may not work without it.
  • About K
  • Academics
  • Admission
  • Alumni Relations
  • Giving to K
  • News & Events
  • Student Life
  • HORNET HIVE
  • ATHLETICS
  • SITEMAP
  • WEBMAIL
    • Login
    View Item 
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Chemistry
    • Chemistry Senior Individualized Projects
    • View Item
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Chemistry
    • Chemistry Senior Individualized Projects
    • View Item

    Antiphospholipid Antibodies Interact with Neutrophil Extracellular Traps: a Novel Mechanism of Thrombosis in the Antiphospholipid Syndrome

    Thumbnail
    View/Open
    Searchable PDF / Kalamazoo College Only (10.02Mb)
    Date
    2014
    Author
    Morris, Alexandra E.
    Metadata
    Show full item record
    Abstract
    Antiphospholipid syndrome is an autoimmune disorder that causes thrombosis and pregnancy complications with no targeted treatment available. Antiphospholipid antibodies (aPLs) against β2GPI have been known to activate monocytes, platelets, and endothelial cells, leading to vascular damage and clot formation. Neutrophil extracellular traps (NETs) are a recently discovered phenomenon known to have both arterial and venous pro-thrombotic implications, however their relationship with aPLs has not been previously studied. This research examined the link between aPLs and neutrophils, investigating whether these antibodies induce NET formation, leading to thrombosis. Indeed, β2GPI was found on both resting neutrophils and NETs and β2GPI appears to be present at extremely high levels when NETs are induced in the presence of plasma. Furthermore, β2GPI-DNA complexes form not just in vitro, but were also detected at significantly higher levels in APS plasma and serum samples as compared to healthy controls. Additionally, β2GPI appears to co-localize with CD32a on neutrophils with potential for modulating downstream effects. Thus, it was determined that aPLs interact with NETs, providing the basis for a novel therapeutic target for APS.
    URI
    http://hdl.handle.net/10920/29958
    Collections
    • Chemistry Senior Individualized Projects [889]

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2021  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV
    Logo

    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602

    About K
    Academics
    Admission
    Alumni Relations
    Giving to K
    News & Events
    Student Life
    Sitemap
    Map & Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official disclaimer
    Search this site


    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar
    DSpace Express is a service operated by 
    Atmire NV