Neurotensin-1 receptor agonist PD149163 interacts with N-methyl-D-aspartate receptor antagonist MK-801 and the effects on working memory
A novel molecule, neurotensin-1 agonist PD149163 targets both the limbic system and dopaminergic areas to increase neurotensin levels, which may play a critical role in the pathogenesis of schizophrenia. A rat model testing working memory utilizing a Barnes maze found that PD149163, when interacting with MK-801, an NMDA receptor antagonist, did not improve induced memory deficits, yet increased induced velocity deficits.
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Receptor-Binding Studies of Agonists and Antagonists at the D2 Dopamine Receptor in Bovine Caudate Francis, Jonathan W. (Kalamazoo College, 1984)Antipsychotic drugs are thought to produce their therapeutic effects in schizophrenia by blocking receptors for the neurotransmitter dopamine in the brain. Several lines of evidence previously indicated, however, that ...
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