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dc.contributor.authorO'Meara, Conor M.
dc.description1 Broadside. Designed using Microsoft PowerPoint. 48"W x 36"Hen_US
dc.description.abstractThe pregnane X receptor (PXR) is a nuclear receptor transcription factor that regulates genes primarily involved in xenobiotic and endogenous chemical disposition and metabolism. A cluster of cytochrome P450 (CYP) genes involved in phase I metabolism are regulated by mammalian PXR. These genes can be broken down into families based on function, with CYP gene families 1-3 acting primarily in metabolism of drugs and xenobiotics such as polychlorinated biphenyls (PCBs). PCBs are a group of highly toxic, synthetic organic chemical compounds ubiquitously distributed with two major classifications: Coplanar PCBs are agonists to the aryl hydrocarbon receptor (AhR), while non coplanar PCBs are thought to act as ligands for members of the nuclear receptor transcription factor family. PCB153 has been shown to activate certain PXR target genes in mammalian cell lines, and PCB126 has been shown to induce expression of target genes under PXR regulation in vivo in zebrafish (Danio rerio). However, the pathway between PXR and its putative activators and target genes is poorly understood in non-mammalian vertebrate species. As such, we used zebrafish to investigate PXR function.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2014en_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleStudy of the pregnane X receptor in the non-mammalian vertebrate species Danio rerio: polychlorinated biphenyl activation and cytochrome P450 regulationen_US

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  • Diebold Symposium Posters and Schedules [479]
    Poster and oral presentations by senior biology majors that include the results of their Senior Integrated Projects (SIPs) at the Diebold Symposium. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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