Ghrelin Reduces Infiltrating Inflammatory Cells After Traumatic Brain Injury

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Authors
D'Mello, Ryan H.
Issue Date
2014
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Presentation
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en_US
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Abstract
• Traumatic Brain Injury (TBI) pathophysiology has two injury phases: primary mechanical assault and secondary indirect injury. • The TBI- induced inflammatory response is mediated by the activation of resident microglia, infiltration of leukocytes, and release of proinflammatory cytokines at the site of injury. • Ghrelin, an endogenous ligand for GHSR-1a, has recently been shown to have anti-inflammatory properties and be beneficial in the pathology of TBI. • The present study sought to determine whether Ghrelin treatment post-TBI would affect the recruitment or infiltration of inflammatory cell populations, including microglia, monocytes/neutrophils, and lymphocytes. Furthermore, this study aimed to determine if Ghrelin regulates the activation state of resident microglia.
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Kalamazoo, Mich. : Kalamazoo College
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U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
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