Sex Differences in the Physiological and Subjective Effects of Oral THC
MetadataShow full item record
With the recent increase in marijuana use and abuse, development of a potential therapeutic treatment for marijuana dependence has become increasingly important to research. Oral D9-tetrahydrocannabinol (THC) is one possibility for the treatment of marijuana dependence. However, recent research has been unable to confirm the presence or absence of a sex difference in response to oral THC. To investigate the possibility of a sex difference, 25 cannabis dependent adults (13 male; 12 female) were given three different doses of oral THC in a within subject design. After ingestion of the dose, subjective responses and physiological data were measured for each participant. Significant sex differences were found in all three of the visual analog scale (VAS) categories (drug effect, craving and mood variables) and for two of the physiological variables (i.e. heart rate and systolic blood pressure). Results from this study indicate that there is a sex difference in the effects of oral THC in a laboratory environment, and support the need for additional research into this difference before oral THC is recommended as a potential therapeutic treatment for marijuana dependence..