Deferoxamine Accelerates Consolidation Periods during Distraction Osteogenesis in Murine Mandibles
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Authors
Johnson, Kelsey L.
Issue Date
2012
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Craniofacial abnormalities are often difficult to correct due to a multitude of physiologic
interacting elements. Nevertheless, successful treatments have become possible due to
increasing knowledge of the complex mechanisms of bone rehabilitation. Distraction
osteogenesis (DO) is a clinically accepted surgical therapy used to remediate a number of
deformities associated with the craniofacial skeleton. Although DO has proven to be an
incredibly effective therapy, the length of time required for successful consolidation renders
patients vulnerable to infection and delays their return to normal activities of daily living.
Finding techniques to optimize consolidation periods could limit these morbidities, and further
advance the immense therapeutic potential of this surgical procedure. Understanding detriments
in vascularity during bone regeneration has offered exploitable avenues for the optimization of
DO. This study looked to animal experimental models with murine rodents to accelerate
consolidation periods during mandibular DO using Deferoxamine (DFO) as an angiogenic
enhancing therapy to bolster vascular response in bone regeneration. While bony unions
observed both grossly and radiographically were expected to form for both the control and
experimental groups for the 28 day consolidation period, unions were discovered at the earliest
consolidation time point of 14 days. These results suggest that DFO’s role in enhancing
vascularity led to increases in the number of bony unions and shortened the conventionally
accepted time parameter of consolidation periods by 50%. Further analysis should confirm that
the addition of DFO does in fact improve bone quality during DO, ultimately leading to the
expansion of reconstructive capabilities for craniofacial surgeons in the future.
Description
iv, 30 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.