Endurance Exercise and Effects on Mobility and Cardiac Healthspan in Drosophila
Daniels, James P.
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Endurance exercise slows age-related functional decline and alters the metabolic health of an organism. Endurance training leads to remodeling events in both cardiac and skeletal muscle. However, the genetic factors governing exercise response are still not well understood. The recent development of invertebrate models for endurance exercise is likely to lead to experimental designs that examine the interactions between exercise and genetics. Using the Drosophila model we are able to describe the effects of endurance exercise on physiological indices such as climbing speed and fatigue tolerance. Additionally, we use dissected cardiac muscle to analyze the effects of exercise on myocardial lipid storage and autophagy levels. The effects of exercise on Drosophila were assessed in four different backgrounds of flies: Berlin K, CS[W], Ra and La .When flies age they suffer age-related decline in mobility and a reduction in fatigue tolerance and weakened cardiac function. Exercise training during the first three weeks of life promotes increased mobility and a greater fatigue tolerance. It was found that endurance exercise had no significant effect on lipid accumulation and increased autophagy in a tissue-specific manner. A clear sexual dimorphism was found in the mobility assays. We can conclude that endurance exercise induced protection against age related decline in mobility and cardiac function.