ABOUT K
ACADEMICS
ADMISSION
ALUMNI RELATIONS
GIVING TO K
NEWS & EVENTS
STUDENT LIFE
HORNET HIVE
ATHLETICS
SITEMAP
WEBMAIL
    • Login
    View Item 
    •   DSpace Home
    • Academic Departments, Programs, and SIPs
    • Chemistry
    • Chemistry Senior Individualized Projects
    • View Item
    •   DSpace Home
    • Academic Departments, Programs, and SIPs
    • Chemistry
    • Chemistry Senior Individualized Projects
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Combined Treatment of Amifostine and Deferoxamine Restores Bone Mineral Beyond Normal Fracture Healing

    Thumbnail
    View/Open
    Searchable PDF / Kalamazoo College Only (1.022Mb)
    Date
    2012
    Author
    Colonius, Anne K.
    Metadata
    Show full item record
    Abstract
    Radiotherapy is a valuable tool in the management of Head and Neck Cancer (HNC) patients. Despite its usefulness in increasing survival for patients with HNC, the use of radiotherapy has been known to have detrimental effects to bone.1 Osteoradionecrosis and pathologic fractures are known to occur in 5%-10% of patients after high dose radiotherapy to the jaw. Currently there are no therapeutic options known to circumvent the development of ORN and pathologic fractures in this setting. Radiation is known to cause vascular diminution and reduction in the number and function of osteocytes, which can ultimately lead to the devastating sequelae of ORN and pathologic fractures.4.s A combined therapy of Deferoxamine (DFO)-a vascular augmentation therapy and Amifostine (AMF)-a cellular radioprotectant, was utilized on a radiation induced non-union rat model to investigate these aberrant effects. Micro Computed Tomography {JlCT} was used for tissue examination of bone for osteocyte count, and gross inspection of fractured mandibles after dissection was used to assess for bone union as outcome measures. A significant restoration of bone volume fraction (BVF) (p = 0.000) and osteocyte count (Oc) (p = 0.000) was found when comparing radiated fractures to radiated fractures treated with combination therapy. Further, these metrics were comparable to nonradiated bone that had undergone fracture repair (BVF-p = 0.746; Oc-p = 0.064), indicating that normal fracture healing was apparent despite the effects of radiotherapy in treated samples. Ultimately, on gross inspection, non-radiated fractures exhibited 100% bony union, radiated fractures exhibited 25% bony union, and radiated fractures with combination therapy exhibited 80% bony union. In conclusion, the combination of DFO and AMF may be a useful clinical therapeutic strategy in the management of ORN, pathologic fractures and prevention of nonunions after radiotherapy.
    URI
    http://hdl.handle.net/10920/28848
    Collections
    • Chemistry Senior Individualized Projects [827]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
     

     

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

    My Account

    Login

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
     

     

    K logo
    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602
    ABOUT K
    ACADEMICS
    ADMISSION
    ALUMNI RELATIONS
    GIVING TO K
    NEWS & EVENTS
    STUDENT LIFE

    Sitemap
    Map and Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official Disclaimer
    Search this site





    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar