The Fabrication of Naphthyl Bromide Polylactide and Its Potential Clinical Applications
Loading...
Authors
Paule-Carres, Michael
Issue Date
2013
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
A decrease in an organism's normal oxygen concentration, either in tissue
systems or intracellularly, is typically a sign that it is undergoing some form of
physiological abnormality that threatens its overall health. However, despite the
documented necessity of molecular oxygen in the majority of living tissue, up to this
point no satisfactory method of monitoring this molecule spatially and temporally
has been put forth. Recently though, attention has been turned to phosphorescent
dyes that are susceptible to oxygen quenching as a potential answer to this problem.
In particular, a new class of compounds known as boron beta-dik~tonates exhibit
unusual and exciting luminescent properties, such as dual emission of both
fluorescence and phosphorescence at room temperature, that provide
encouragement that they could be used toward developing an oxygen-sensitive dye
for clinical application for monitoring the body's response to health concerns such
as cutaneous wounds and malignant tumors. In this project, the beta-diketonate
molecule difluoroboron napthyl bromide was synthesized in an attempt to
characterize its properties for these purposes. While the overall synthesis of the.
polymer was unsuccessful due to a faulty catalyst, the steps preceding its use
exhibited pure compounds at high yields, suggesting that continued attempts at the
molecule's production should be performed.
Description
25 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.