The Fabrication of Naphthyl Bromide Polylactide and Its Potential Clinical Applications
MetadataShow full item record
A decrease in an organism's normal oxygen concentration, either in tissue systems or intracellularly, is typically a sign that it is undergoing some form of physiological abnormality that threatens its overall health. However, despite the documented necessity of molecular oxygen in the majority of living tissue, up to this point no satisfactory method of monitoring this molecule spatially and temporally has been put forth. Recently though, attention has been turned to phosphorescent dyes that are susceptible to oxygen quenching as a potential answer to this problem. In particular, a new class of compounds known as boron beta-dik~tonates exhibit unusual and exciting luminescent properties, such as dual emission of both fluorescence and phosphorescence at room temperature, that provide encouragement that they could be used toward developing an oxygen-sensitive dye for clinical application for monitoring the body's response to health concerns such as cutaneous wounds and malignant tumors. In this project, the beta-diketonate molecule difluoroboron napthyl bromide was synthesized in an attempt to characterize its properties for these purposes. While the overall synthesis of the. polymer was unsuccessful due to a faulty catalyst, the steps preceding its use exhibited pure compounds at high yields, suggesting that continued attempts at the molecule's production should be performed.