JavaScript is disabled for your browser. Some features of this site may not work without it.
  • About K
  • Academics
  • Admission
  • Alumni Relations
  • Giving to K
  • News & Events
  • Student Life
  • HORNET HIVE
  • ATHLETICS
  • SITEMAP
  • WEBMAIL
    • Login
    View Item 
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Diebold Symposium Posters and Schedules
    • View Item
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Diebold Symposium Posters and Schedules
    • View Item

    Behavioral Characterization of a Graded, Bilateral Cervical Spinal Cord Contusion Injury in Rats

    Thumbnail
    View/Open
    LeeIsabel_Diebold.pptx (1.028Mb)
    Date
    2013
    Author
    Lee, Isabel B.
    Metadata
    Show full item record
    Abstract
    Spinal cord injury (SCI) is estimated to affect roughly 1.28 million individuals in the U.S. today and continually increases with 12,400 new incidences yearly. The effects of SCI result in varying complications that depend on impact magnitude and location along the spinal cord. Cervical SCI jeopardize fundamental functions for survival like respiratory capability and locomotive abilities including motor and sensory transmission and autonomic nervous system functions. A fifth of the cervical SCI population are mechanistically due to compression or contusion of the cord. Thus, a clinically-relevant and reproducible cervical contusion SCI model in experimental settings is important for the improved clinical translation of putative pharmacological therapeutic modalities. The Infinite Horizons (IH) Impactor (with a modified 4 mm probe) was used to create a cervical C5 SCI at graded severities, and an array of varying behavioral tests were utilized to assess overall rat fore- and hindlimb performance. The 200 kilodynes (kdyn) severity group would be the optimal force setting used on the IH Impactor in rat models because the force was strong enough to create moderately severe functional deficits without compromising basic functions of life.
    URI
    http://hdl.handle.net/10920/28654
    Collections
    • Diebold Symposium Posters and Schedules [479]

    Browse

    All of CACHECommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV
    Logo

    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602

    About K
    Academics
    Admission
    Alumni Relations
    Giving to K
    News & Events
    Student Life
    Sitemap
    Map & Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official disclaimer
    Search this site


    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar
    DSpace Express is a service operated by 
    Atmire NV