Show simple item record

dc.contributor.authorde Waal, Parker W.
dc.description1 Broadside. Designed using Adobe Illustrator. 48"W x 36"Hen_US
dc.description.abstractProstate cancer (PC) is the second leading cause of male cancer-related deaths in the United States. The central molecule in the development and progression of PC is the androgen receptor (AR), which serves as the most therapeutically relevant target for chemoprevention and drug therapy. First generation AR antagonists, such as bicalutamide and flutamide, exhibit only partial receptor antagonism prompting continued cancer proliferation and metastasis. Thus, the development of more powerful AR antagonists that exhibit pure antagonistic activities would prove to be of great therapeutic value. Unfortunately, despite more than 20 years of crystallization effort focused on the AR, a ligand binding domain (ARlbd) antagonist bound crystal structure remains elusive due to poor expression and and an inherently low protein solubility. In this study we propose a system using phage assisted continuous evolution (PACE; Figure 1.), a novel technique for directed evolution, to overcome the inherently low soubility exhibited by ARlbd to aid in ongoing crystallization efforts.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2013en_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleDevelopment of Phage Assisted Continuous Evolution of the Human Androgen Receptoren_US

Files in this item


This item appears in the following Collection(s)

  • Diebold Symposium Posters and Schedules [479]
    Poster and oral presentations by senior biology majors that include the results of their Senior Integrated Projects (SIPs) at the Diebold Symposium. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

Show simple item record