Central Carbon Production During the Blood-Stages of Proliferating Plasmodium falciparum
VanDyke, Jesyca L.
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Introduction Since around 2800 B. C. nearly half of the world’s population has been at risk for contracting malaria (1, 2). Currently speaking there are 2.5 billion people living in malaria endemic areas and at any given time there are 100 million individuals living with the clinical symptoms of the disease (3). The purpose of this paper is to review some of the major central carbon production pathways, namely glycolysis and the TCA cycle, in the malaria-causing P. falciparum parasite. These cellular pathways are currently the buzz for anti-malarial research. P. falciparum and human cells are eukaryotic and therefore have comparable metabolic frameworks. The metabolic processes between these cells will be discussed for illumination of the divergence between the two genomes. This review will shed light on the branched metabolic framework with which P. falciparum has been discovered to operate.