Length and Volumes of Frontal, Occipital, and Temporal Lobes in Multiple affected Families with Schizophrenia
Jasin, Stephanie L.
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Schizophrenia is a severe, life-long disabling disorder, the origins of which are unknown. However, we do know that there is a genetic basis to schizophrenia. To further examine this basis, we measured the lengths of the frontal, temporal, and occipital lobes of 82 subjects in a cohort of 27 multiple affected families with schizophrenia. In addition, we determined the frontal lobe volumes of the parents of the patients in this study. We found a strong, statistically significant correlation between the length and the volume measurements in the parents. Using length parameters should give a good estimate of the physiological asymmetries of the lobes found in healthy, right-handed subjects. These are only partial results due to time constraints in the research.