Validation of Subclassification Groups In Tourette's Syndrome Using a Community Sample
Primeau, Elizabeth C.
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Research on the pathophysiology of Tourette's syndrome has been confounded by the occurrence of comorbid syndromes. Therefore, studies are often unclear on whether the findings are a result of (1) "pure" Tourette's (e.g., tic symptoms only), or the comorbid disorders of (2) Attention Deficit Hyperactivity Disorder, (3) Obsessive-Compulsive Disorder, or ( 4) both Attention Deficit Hyperactivity Disorder and Obsessive-Compulsive Disorder. A previous study by Behen, Muzik, Helder, Rothermel, Perry, and Chugani (in press) recruited participants who had been diagnosed with Tourette's by a pediatric neurologist, meaning their symptoms were likely to be of greater severity. The proposed study is a continuation of the study by Behen et al., using a sample of300 children and adolescents (ages 5 to 18 years) from the community. Participants will be recruited from the Michigan Chapter of the Tourette Syndrome Association. In using a community sample, it is predicted that participants' symptoms will have a wider range of severity than participants from the previous study. Participants' caregivers will complete a battery of behavioral assessment scales and a social history interview about the child. The majority of the assessment scales and interview materials include more detailed questions and are, overall, more extensive than the scales used in the study by Behen et al. The added depth to these assessment measures is necessary to differentiate the four subgroups from one another.