Maternal Diet Affects Fat Taste Receptor Protein Expression in Rat Pups

Loading...
Thumbnail Image
Authors
Daniels, Malcolm
Issue Date
2012
Type
Thesis
Language
en_US
Keywords
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract
Obesity rates of children in the developed world are increasing dramatically. This is due in part to the high availability of foods high in fat combined with an evolved dietary preference, in humans and other mammals, for high-fat foods. Knock out of receptor proteins involved in fat taste have been shown to protect against diabetes and weight gain. In this study female rats of two distinct rat lines, S5B obesity-resistant and O-M obesity-prone, were given either normal or high-fat diets while pregnant and through lactation until the pups were weaned. The pups’ expression levels of five receptors involved in fat taste, CD36 GPR120, Kv1.5, Kv2.2, and Kv3.2, were measured using real-time quantified PCR. Maternal diet was found to have a marked effect on gene expression in pups. High-fat diets elevated the expression in some measured receptors (Kv1.5, Kv2.2), decreased expression in one (CD36) and had no effect in others (GPR120, Kv3.2). Due to the complex relationship between fat levels and receptor expression, as well as receptor expression and health, differential intake of certain fats may help improve offspring health and reduce fat preference.
Description
iii, 27 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
Journal
Volume
Issue
PubMed ID
DOI
ISSN
EISSN