Gastrointestinal Permeability of Model Solutes and Halofuginone in the 7-14 Day Old Chicken
Oelslager, Barbara A.
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In this study, we developed a useful method for determining the absorption kinetics of model permeants and coccidiostats in the chick intestine. The transport barrier of the aqueous boundary layer was quantified and found to be similar in terms of its impact on the absorption of at least one lipophilic permeant (salicylic acid) to that already characterized in the rat. Baseline data was generated on the absorption of halofuginone, an important non-polyether coccidiostat, against which other coccidiostats and experimental compounds can be compared. The present study was also a first step toward defining characteristics of the chicken intestine which are essential to the eventual development of a comprehensive model for predicting the behavior of drugs in this system. Future studies should address such issues as drug absorption by the epithelium of the ceca, regional variations in drug residence times, comparisons of halofuginone with polyether ionophore coccidiostats (e.g. monensin), and the influence of coccidial infection on absorptive properties of the chick intestine.