The Effects of Cocaine and AJ-76 on Glucose Metabolism in Rat Brain
Mead, Brenda L.
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The 2-deoxy-D-[14 C] glucose method was used to map local cerebral glucose utilization (LCGU) metabolic responses to cocaine and AJ-76 in the rat brain. The effects of three doses of AJ-76, cis-(+)-5-methoxy-1-methy-2-(n-propylamino)tetralin, had almost no statistically significant effect, with the exception of a depression of LCGU in the spinal cord at the highest dose (15 mg/kg). cocaine significantly increased glucose metabolism in six of 64 measured areas. When cocaine administration was followed by AJ-76 this drug antagonized cocaine's stimulant effects in five of the six areas. No statistical increase was seen in the nucleus accumbens after cocaine administration. The ability of AJ-76 to antagonize cocaine's action in the brain suggests that this drug may have a therapeutic value in treating cocaine addiction.