Treatments for Spinal Cord Injuries Based on the Four Strategies of Treatment
An injury to the spinal cord can cause an irreversible and permanent damage to the axons in the spinal cord. The two currently available treatments are Methylprednisolone and neural prosthetics. Methylprednisolone are promising treatments for SCis that can promote functional compensation and retention, respectively, but they do not repair the damaged spinal cord to its pre-injury state. Although a treatment that can repair a damaged spinal cord is unavailable, research using stem cells and stem like precursor cells as a treatment option may allow this to occur. In this paper, the efficacy of each treatment using stem cells like the human embryonic stem cell and neurospheres and stem-like precursor cells like olfactory mucosal cells, bone marrow cells, and precursor cells derived from the skin are evaluated using the four strategies of treatment, making SKP-SCs the best treatment option especially when comparing treatment options that may be available in the near future. The ability to apply these treatments to clinical settings was also a factor when considering the efficacy of a treatment, finding precursor cells a more viable treatment option compared to stem cells. The combination of two treatments in a study lead by Dr. Peduzzi showed that olfactory mucosal and bone marrow cells work antagonistically. Future studies are required to help elucidate the cause of this problem and allow these treatment groups to proceed into clinical trials.
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