An In-Depth Analysis of C-Reactive Protein's Role in Explaining the Link Between Periodontal Disease and Cardiovascular Disease
Gietzen, Benjamin T.
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The association between periodontal disease and cardiovascular disease has recently been a growing issue worldwide. Periodontal disease, an oral disease that results in infection and inflammation, and cardiovascular disease, a systemic disease that is caused by infection and inflammation, have long been suggested to be associated with each other, but there have previously been difficulties with gathering evidence to demonstrate ah association. Epidemiological studies demonstrate that severe periodontal disease is associated with an increased risk for cardiovascular disease, but the mechanisms are rather unclear. However, recently there has been growing attention to the concept that C-reactive protein, an inflammatory biomarker that elevates during periods of infection and inflammation, has a direct role in the pathogenesis of cardiovascular disease and that it could be the link that associates periodontal disease with cardiovascular disease. There have been many proposed functions of C-reactive protein that could suggest its role in the pathogenesis of cardiovascular disease, but the concept is still new and further studies need to be· conducted on C-reactive protein's functions during periods of inflammation to validate C-reactive protein as a link between periodontal disease and cardiovascular disease.
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