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dc.contributor.advisorYourick, Debra L.
dc.contributor.authorButera, Amy
dc.date.accessioned2012-02-13T16:02:38Z
dc.date.available2012-02-13T16:02:38Z
dc.date.issued1994
dc.identifier.urihttp://hdl.handle.net/10920/24959
dc.descriptioniv, 48 p.en_US
dc.description.abstractMale Sprague-Dawley rats were injected for 15 consecutive days with either desipramine (25 mg/kg in 0.9% NaCI solution with 10% DMSO) or vehicle (0.9% NaCI solution with 10% DMSO). On the 16th day, the rats were decapitated by guillotine, and the brain was removed and dissected for specific regions. Assays measuring NAALADase activity were then conducted for each region by utilizing NAAG radiolabelled at the glutamate residue. Data from this experiment exhibited a significant difference in the NAALADase activity between DMI and vehicle treated subjects in pyriform cortex. A distinct rostral-caudal NAALADase concentration gradient was also found to be present throughout studied regions of brain.en_US
dc.description.sponsorshipWalter Reed Army Institute of Research. Washington, D.C.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleThe Effects of Desipramine on NAAG Hydrolyzing Enzyme, NAALADaseen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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