The Pharmacokinetics of PNU-177553 in Normal and Uninephrectomized Rats
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Authors
El-Shamaa, Nancy N.
Issue Date
2001
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
PNU-177553 is an oxazolidinone drug candidate for a community use antibiotic (Stryd,
et aI, Phannacia Corporation, 1999). Renal excretion is one of the major pathways of
elimination of PNU-177553, an antibacterial compound, in animals and in humans.
Renal function impairment affects the pharmacokinetics of PNU-177553, which were
studied in selective models of renal impairment induced by uninephrectomized rats. This
study evaluated the pharmacokinetics of PNU-177553 in rats with induced renal function
impairment. Timed plasma samples were collected after administration of a single dose
(either of high concentration or of low concentration) of PNU-177553 to groups of rats
with induced renal function impairment and in control animals. The concentrations of
PNU-177553 in the plasma and urine samples were assayed. The pharmacokinetics were
compared between control rats with normal renal function, uninephrectomized rats, and
between rats that received high doses of the compound and rats that received low doses
of the compound. The objectives of the studies were to evaluate the changes in the
pharmacokinetics of PNU-177553 in rats with induced renal function impairment and
whether the phannacokinetics differ between the two doses of PNU-177553
administered. The study may provide useful data for understanding of renal elimination
of PNU-177553 and other drugs in humans.
Description
26 p.
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